CoQ10 is a vitamin-like substance required by the body to transform food into cellular energy. Amazingly, it is so essential to life processes that, without it, life would cease to exist in a matter of minutes! How can this be? To answer this question, let’s back up a few steps and take a microscopic look at the cells in our body.

CoQ10 is essential to energy production in the body. Without sufficient CoQ10, none of the systems in the body can function optimally because they simply do not have enough fuel to do their job. The systems most sensitive to deficiencies are those with high energy needs such as the cardiovascular and immune systems. In addition to energy production, CoQ10 also offers important antioxidant protection in the cells. It is believed that the combination of antioxidant protection and energy production creates the clinically documented benefits people experience when they supplement with CoQ10. As with all nutrients, the most bioavailable form is that found in whole food. A recent study concluded that whole food CoQ10 offered 9.6 times more antioxidant activity than the isolated chemical USP form found in almost all supplements.

CoQ10 is a vitamin-like substance required by the body to transform food into cellular energy. Amazingly, it is so essential to life processes that, without it, life would cease to exist in a matter of minutes! How can this be? To answer this question, let's back up a few steps and take a microscopic look at the cells in our body. Each of our cells are self-contained little units with their own tasks, agendas and needs. Just as the whole body requires energy to work, so does each individual cell. Our cells produce energy to fuel their work and that, in turn, fuels the entire body. The mitochondria within each cell are the energy generators. If our cells (or bodies) were automobiles, the mitochondria would be the engines, and food would be the gasoline.

This is when CoQ10, also known as ubiquinone, enters the picture. During digestion, much of what we eat is converted to glucose to be used as fuel. However, the mitochondria must further reduce the glucose before it is usable by the cells. To accomplish this, the cell and its mitochondria use several complicated processes and substances that convert glucose to ATP, or cellular energy. CoQ10 is required for these processes.

Although CoQ10 may be synthesized in the body and found in food, deficiencies do exist. Refining and processing robs our food supply of this essential nutrient. Moreover, to synthesize CoQ10, the body must have a healthy liver and an adequate supply of other nutrients that are also often lacking in the diet. Consequently, after about age 35, CoQ10 levels in the body begin to diminish. Studies have shown that if levels decline by 25%, our bodies won't have enough cellular energy to stay healthy. A decline of 75% is fatal.

To understand the enormous impact CoQ10 levels have on our health, we must keep in mind that diminished cellular energy is different from our colloquial use of the word "energy". In common language, we often say "I don't have the energy to______." Rarely are we referring to life sustaining activities. The statement usually refers to leisure activities, housework, an evening out, or physical exercise. While any of these things may improve our health, our immediate survival does not depend upon them. Such is not the case with cellular energy. Our lives do, literally, depend upon our cells having enough energy to do their work. Consider for a moment heart cells. Heart cells have one job-to sustain rhythmic contraction and release in the heart muscle so that oxygen and nutrient rich blood is delivered to the cells and oxygen-depleted, carbon dioxide rich blood is carried away. If these cells don't have enough energy to do their work, you have an immediate, major, life threatening problem. Your heart cells don't have the luxury of reclining on the sofa until their "energy" returns!

When scientists and researchers first began to study CoQ10, they found the highest concentrations in the heart, the immune system and the liver. This makes sense as these are also the cells that require the most energy. Focusing on these CoQ10 hungry cells, research and clinical trials began to reveal some very impressive findings and results. They first found that people with poor health have insufficient levels of CoQ10 in their systems while healthy people have normal levels of this vital nutrient. This finding lead scientists to explore the effects of supplementing with oral CoQ10. Truthfully, their findings have been remarkable. A multitude of clinical trials demonstrated that CoQ10 is very useful in the treatment and prevention of congestive heart failure, angina, arrhythmia, myocardial degeneration and high blood pressure. In one study 80% of patients with severe congestive cardiomyopathy showed significant improvement after they began supplementing daily with CoQ10. In another, over 50% of high blood pressure patients were able to eliminate their hypertension medications after 5 months of daily CoQ10 use. The American Heart Associations rank the severity of a patient's heart disease with a class system. This system ranges from mild Class I heart disease to severe Class IV heart disease. Often clinical trials use this ranking system when evaluating their participants' progress. In England, an eight year clinical trial of patients with various cardiovascular diseases found 58% of the participants improved by one Heart Association Class; 28% improved by two classes! This same study also found significant improvement in the thickness of the left ventricular wall of the heart and mitral valve flow. CoQ10 is such a powerful ally in heart health that Japanese physicians recommend it regularly to over 12 million of their patients. Imagine the positive effects of supplementing with CoQ10 before serious problems develop! The Medical Hypotheses journal published in England suggested that preventative supplements would be more useful as "insurance" if CoQ10 was regularly included.

Studies on CoQ10 and the immune system have resulted in similar findings. Like the cardiovascular system, the immune system is highly energy-dependent. After all, it has a huge job. Conditions such as allergies, Candida overgrowth, cancer, AIDS, chronic fatigue, and periodontal disease are all a result of immune system dysfunction. Immune system function does decline with age, stress and poor nutrition. Fortunately, studies reveal that CoQ10's effect on the immune system is as beneficial as its effect on the cardiovascular system. Numerous clinical trials have documented an overall improvement in immune system function among the participants using CoQ10 daily.

CoQ10 improves function of the cardiovascular and immune systems simply by providing the cells with the raw material they need to function optimally. It allows the cells, and therefore the systems, to express their full potential. Without sufficient CoQ10, these systems (along with many others) are handicapped. There is simply no way they can perform their jobs at the level needed to sustain good health-they don't have the energy!

CoQ10 protects our health in yet another profoundly significant way. As CoQ10 levels decline, the incidence of symptoms we associate with aging tend to increase. This is related not just to insufficient cellular energy, but also to CoQ10's antioxidant activity. Too little oxygen in a cell results in a lack of energy; too much results in free radical damage. CoQ10 balances the oxygen through adding or subtracting oxygen from biologically active molecules. This is why it is important to actually have more CoQ10 in the cell than is required for ATP production. The excess CoQ10 is able to offer superior antioxidant protection while at the same time enabling the cell to produce its full capacity of energy.

Supplementing the diet with any nutrient is always a tricky business. There is no question among researchers, scientists and healthcare providers that the safest, most effective forms of nutrients are those in whole food forms. The reason for this is actually quite simple. In food, no one compound occurs in isolation. A multitude of compounds travel together, supporting and enhancing each other's efficacy and efficiency. This cooperation naturally produces checks and balances that promote safety and potency. Conversely, in most supplements, what you find is one, chemically manufactured, isolated USP compound. Sometimes companies add a few other ingredients to support the active ingredient, but that does not even begin to replicate the complexity and synergy found in whole food. This lack of complexity and synergy makes it necessary to take much higher doses of isolated nutrients than one actually needs. This is due to the fact that we are not certain how much of an isolated nutrient the body is able to absorb and utilize; neither are we certain how much a nutrient's efficacy may be diminished by the absence of its traveling companions.

Thankfully, it is now possible to purchase supplements that are 100% whole food. In these supplements, there are no compounds in isolation. All the nutrients are traveling with the support of their naturally occurring companions and allies. The synergistic benefits inherent in this "companionship" are multiple. Dr. Joe Vinson, Professor of Chemistry at University of Scranton, found that whole food CoQ10 offered 9.6 times more antioxidant activity than an identical potency of isolated USP CoQ10. That is a significant difference! Not only is whole food CoQ10 more bioavailable and active in the body, it also provides the health-enhancing compounds found in the naturally occurring co-factors or "companions".

The body's need for CoQ10 never diminishes. As long as we are breathing, we need CoQ10. After a deficiency has occurred, studies indicate that it takes some time for tissue levels to rebuild. For this reason, it is advisable to supplement with CoQ10 for at least 5-6 months before evaluating its beneficial effects.

Eliza Secrist is a Certified Nutritionist and Wellness Consultant. The former Director of a Women's Resource Center and the Clinic Manager of a Women's Health Center, she has been teaching and counseling for 10 years.

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Folkers, K. and Yamamura, Y. eds, Biomedical and Clinical Aspects of CoQ10, Vol. 4. Amsterdam: Elsevier Science Publishers, 1984.

Research on CoQ10 in clinical medicine and in immunomodulation. Switzerland: Drugs Exp Clin Res, 1985; 539-45.

Blizankov, EG. Immunological senescence in mice and its reversal by CoQ10. Mech Aging Dev, 1978; 7:189

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Apparent partial remission of breast cancer in 'high risk' patients supplemented with nutritional antioxidants, essential fatty acids and CoQ10. England: Mol Aspects Med, 1994;15.

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*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

The COX-2 enzyme is naturally created in every one of us. It is considered by many to be stimulated by injury or some form of attack on the body. Simply put, it controls the creation of a hormone-like substance that creates “inflammation.” And not just the common inflammation many experience in a knee or shoulder, but also inflammation throughout the body, even in the brain of an Alzheimer’s sufferer. Scientists now have convincing evidence, from decades of research, that the unchecked activity of this enzyme is responsible for many forms of cancer (including colon, skin, bladder, esophagus, and pancreas), arthritis, and Alzheimer’s Disease.

The COX-2 Medical Revolution

Both the Wall Street Journal and the New York Times have recently proclaimed the revolutionary promise of COX-2 enzymatic inhibition. The Wall Street Journal described the inhibition of this enzyme as a “future milestone in preventative medicine” that stands alongside the polio vaccine and the worldwide eradication of smallpox. Even more remarkably, The New York Times in January of this year announced that COX-2 inhibition not only reduced arthritic inflammation and menstrual pain, but also appears to “prevent cancers of the colon, esophagus, skin, and bladder.” What is this important COX-2 enzyme, and how can it be safely inhibited?

The COX-2 enzyme is naturally created in every one of us. It is considered by many to be stimulated by injury or some form of attack on the body. Simply put, it controls the creation of a hormone-like substance that creates “inflammation.” And not just the common inflammation many experience in a knee or shoulder, but also inflammation throughout the body, even in the brain of an Alzheimer’s sufferer. Scientists now have convincing evidence, from decades of research, that the unchecked activity of this enzyme is responsible for many forms of cancer (including colon, skin, bladder, esophagus, and pancreas), arthritis, and Alzheimer’s Disease.

Amazingly, this fundamental cause of many of our most threatening diseases was only discovered within the past few years, and drug companies immediately began the race to come up with pharmaceutical substances to inhibit the enzyme’s devastating effects. Research scientists around the world supported this effort to create synthetic COX-2 inhibitors, and there was a wonderful, and surely unexpected, benefit of that research. The scientists tried to find plant compounds and herbs to synthetically copy or mimic, and they identified many traditional herbs that contain natural and safe COX-2 inhibitors. The very process to create synthetic COX-2 prescription drugs has thus located herbal constituents that are naturally available, without prescription.

It is important to understand how the enzyme works to create threatening disease conditions. The full name of the COX-2 enzyme is “cyclooxygenase-2,” and its name contains the first clue as to how the enzyme works. Cyclooxygenase has the job of “oxidizing,” or burning, a fat in the body called “arachidonic acid.” This fat is an Omega 6 fatty acid, and it occurs naturally in all of our cell membranes or walls. Picture the COX-2 enzyme as a “spark plug” that ignites this fat and cooks up inflammatory substances. Simply put, the enzyme is the spark, the fat is the fuel, and the flame of inflammation is the end result.

We need that fire: it helps us defeat enemies like bad bacteria, and it helps the body marshal its forces to respond to trauma and injury. But sometimes the fire burns too hot or gets out of control, and when that happens we can be casualties of “friendly fire.” We can develop some forms of cancer and arthritis, and our very brain neurons can get overheated and die.

This, fortunately, is not a hopeless situation, and one of the most popular drugs in the world helps to inhibit the fires of COX-2 inflammation. That drug is none other than aspirin, which not only inhibits the COX-2 enzyme but also reduces the stickiness of our blood platelets, thus helping to prevent strokes and heart attacks. Unfortunately, aspirin and related “non-steroidal anti-inflammatories” can have very serious side effects, and last year more people died from such side effects than from AIDS. Many people are unwilling to take these drugs on a chronic basis, and many more simply should not.

The great excitement came about a year ago, when a “safe aspirin” named Celebrex® was introduced, and this drug inhibited the COX-2 enzyme without all the negative side effects of aspirin. Unfortunately, this drug, and a related drug named Vioxx®, did not reduce blood platelet stickiness, and there is even some research suggesting that Celebrex could increase platelet aggregation. Most importantly, the drugs are synthetic, and many people either should not or are unwilling to take them.

As we explained above, and in much more detail in our latest book Beyond Aspirin (Hohm Press, 2000), scientists discovered many herbs that can safely, powerfully, and naturally inhibit the COX-2 enzyme. Those herbs include green tea, ginger, turmeric, holy basil, chamomile, Chinese goldthread, barberry, Baikal skullcap, Hu zhang (Japanese knotweed), rosemary, hops, feverfew, and oregano. A blend of the appropriate extracts of those herbs, if sufficiently concentrated, may offer substantial relief from the “fires” of COX-2 inflammation, without the known and unknown side effects of synthetic drug inhibition. This is the genius of nature, and why cultures for thousands of years have obtained healing benefits from extracts of these botanicals.

*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.